The recent publication by Wylie et al. is reviewed, demonstrating that the p53 protein regulates the movement of transposons. While this work presents genetic evidence for a piRNA‐mediated p53 interaction with transposons in Drosophila and zebrafish, it is herein placed in the context of a decade or so of additional work that demonstrated a role for p53 in regulating transposons and other repetitive elements. The line of thought in those studies began with the observation that transposons damage DNA and p53 (...) regulates DNA damage. The presence of transposon movement can increase the rate of evolution in the germ line and alter genes involved in signal transduction pathways. Transposition can also play an important role in cancers where the p53 gene function is often mutated. This is particularly interesting as recent work has shown that de‐repression of repetitive elements in cancer has important consequences for the immune system and tumor microenvironment. (shrink)

This document collects discussion and commentary on issues raised in the workshop by its participants. Contributors are: Greg Frost-Arnold, David Harker, P. D. Magnus, John Manchak, John D. Norton, J. Brian Pitts, Kyle Stanford, Dana Tulodziecki.

This book considers how nature - in both its biological and environmental manifestations - has been invoked as a dynamic force in human history. It shows how historians, philosophers, geographers, anthropologists and scientists have used ideas of nature to explain the evolution of cultures, to understand cultural difference, and to justify or condemn colonization, slavery and racial superiority. It examines the central part that ideas of environmental and biological determinism have played in theory, and describes how these ideas have served (...) in different ways at different times as instruments of authority, identity and defiance. The book shows how powerful and problematic the invocation of nature can be. (shrink)

This is the first book published that specifically examines questions of ethics and advocacy that arise in conducting research on homelessness, exploring the issues through the deeply personal experiences of some of the field’s leading scholars. By examining the central queries from a broad range of perspectives, the authors presented here draw upon years of rich investigations to generate a framework that will be instructive for researchers across a wide spectrum of areas of inquiry.

Titles and abstracts for the Pitt-London Workshop in the Philosophy of Biology and Neuroscience: September 2001.

The cremation of human bodies and the incineration of urban waste provide two interrelated examples of technologies using the destructive power of fire that “travelled” in both directions between India and the West in the nineteenth and twentieth centuries. Rather than granting an automatic ascendency to western ways of burning the dead or disposing of urban rubbish, these case studies indicate the manner in which culture and environment inhibited or prevented their advance and favoured the survival or re-articulation of pre-existing (...) technological practices and the socio-political infrastructure in which they were embedded. In the process of travelling, in part made possible by the agency of colonial personnel and the instruments of imperial exchange, but also through Indian opinion and diasporic dissemination, some technologies substantially changed their meaning, context and material form while others, seemingly untouched, underwent more subtle transformation. (shrink)

The cremation of human bodies and the incineration of urban waste provide two interrelated examples of technologies using the destructive power of fire that “travelled” in both directions between India and the West in the nineteenth and twentieth centuries. Rather than granting an automatic ascendency to western ways of burning the dead or disposing of urban rubbish, these case studies indicate the manner in which culture and environment inhibited or prevented their advance and favoured the survival or re-articulation of pre-existing (...) technological practices and the socio-political infrastructure in which they were embedded. In the process of travelling, in part made possible by the agency of colonial personnel and the instruments of imperial exchange, but also through Indian opinion and diasporic dissemination, some technologies substantially changed their meaning, context and material form while others, seemingly untouched, underwent more subtle transformation. (shrink)

This essay uses the seminal figure of Jawaharlal Nehru to interrogate the nature and representation of science in modern India. The problem posed by Nehruvian science—the conflict between science as both universal phenomenon and local effect—lies at the heart of current debates about what science means for the non-West. The problematic of Nehruvian science can be accessed through Nehru's own speeches and writings, but also through the wider project of science with which he identified—critiquing colonialism, forging India's place in the (...) modern world, marrying intellectual endeavor with practical nation building. The essay makes a case for looking at Nehruvian science as a way of structuring the problem of postcolonial science, particularly in relation to understanding the authority of science and its evaluation in terms of its capacity to deliver socioeconomic change. (shrink)

The ease with which genotyping technologies generate tremendous amounts of data on research participants has been well chronicled, a feat that continues to become both faster and cheaper to perform. In parallel to these advances come additional ethical considerations and debates, one of which centers on providing individual research results and incidental findings back to research participants taking part in genetic research efforts. In 2006 the Industry Pharmacogenomics Working Group offered some ‘Points-to-Consider’ on this topic within the context of the (...) drug development process from those who are affiliated to pharmaceutical companies. Today many of these points remain applicable to the discussion but will be expanded upon in this updated viewpoint from the I-PWG. The exploratory nature of pharmacogenomic work in the pharmaceutical industry is discussed to provide context for why these results typically are not best suited for return. Operational challenges unique to this industry which cause barriers to returning this information are also explained. (shrink)

This book moves toward building a new and more comprehensive theory of literature, philosophy, psychology, and art. The extremely popular work of Ken Wilber, unites the best of both western and eastern thought and affirms that the stages of consciousness, more refined than that of the reasoning mind, do exist.

This paper is about the semantic analysis of referentially opaque verbs like seek and owe that give rise to nonspecific readings. It is argued that Montague's categorization (based on earlier work by Quine) of opaque verbs as properties of quantifiers runs into two serious difficulties: the first problem is that it does not work with opaque verbs like resemble that resist any lexical decomposition of the seek ap try to find kind; the second one is that it wrongly predicts de (...) dicto (i.e. narrow scope) readings due to quantified noun phrases in the object positions of such verbs. It is shown that both difficulties can be overcome by an analysis of opaque verbs as operating on properties. This is a strongly modified version of a paper entitled lsquoDo We Bear Attitudes towards Quantifiers?rsquo that I have presented at conferences in Gosen (Gesellschaft für Sprachwissenschaft), Ithaca (SALT I), and Konstanz (Lexikon). I owe a special debt to Hans Kamp and Arnim von Stechow for shaping my views on the subject of this paper during the past ten years or so. Comments from and discussions with the following friends and colleagues have also led to considerable improvements: Heinrich Beck, Steve Berman, David Dowty, Veerle van Geenhoven, Fritz Hamm, Irene Heim, Wolfgang Klein, Angelika Kratzer, Michael Morreau, Barbara Partee, Mats Rooth, Roger Schwarzschild, Wolfgang Sternefeld, Emil Weydert, Henk Zeevat, and three referees. (shrink)

Through the thickets of recent debates, I take two facts as clear enough starting points. The first is that Heidegger’s participation in National Socialism, and especially his remarks and pronouncements after the war, were, and remain, horrifying. The second is that Heidegger remains of the essential philosophers of our century; Maurice Blanchot testifies for several generations when he refers to the “veritable intellectual shock” that the reading of Being and Time produced in him.5 And Emmanuel Levinas, not hesitating to express (...) his reservations about Heidegger, can nevertheless bring himself to say that a person “who undertakes to philosophize in the twentieth century cannot not have gone through Hiedegger’s philosophy, even to escape it.”6 In this century, perhaps only Ludwig Wittgenstein has had a comparable impact and influence on philosophy. I do not mean to deny that one can reject the over seventy volumes of Heidegger’s Gesamtausgabe as worthless, that one can, as with Wittgenstein, find that his work is obscure, indulgent, impossible to read, that nothing in it contributes to philosophy. But both Heidegger and Wittgenstein write in anticipation of this reaction, recognizing that their desires, differently articulated, to overcome philosophy will help to determine how their writing is received. Stanley Cavell’s characterization of Wittgenstein’s Philosophical Investigations describes Heidegger as well:Philosophical Investigations, like the major modernist works of the past century at least, is, logically speaking, esoteric. That is, such works seek to split their audience into insiders and outsiders ; hence they create the particular unpleasantness of cults ; hence demand for their sincere reception the shock of conversion.7When combined with Heidegger’s political engagement, the particular unpleasantness of cults and indifference are more than joined. Thus it can seem as though one must either exculpate Heidegger, explain away his relation to Nazism as an aberration from the outside, or reject his thought entirely, declare that his books should no longer be read. In an attempt to begin to confront these issues, Critical Inquiry is publishing this symposium. 5. Maurice Blanchot, “Thinking the Apocalypse: A Letter from Maurice Blanchot to Catherine David,” trans. Paula Wissing, p. 479 of this issue.6. Emmanuel Levinas, Ethics and Infinity: Conversations with Philippe Nemo, trans. Richard A. Cohen , p. 42. See also the last line of Gadamer, “ ‘Back from Syracuse?’ “ p. 430.7. Stanley Cavell, The Claim of Reason: Wittgenstein, Skepticism, Morality, and Tragedy , p. xvi; hereafter abbreviated CR. Arnold I. Davidson, a coeditor of Critical Inquiry, is associate professor of philosophy and member of the Committees on General Studies in the Humanities and on the Conceptual Foundations of Science at the University of Chicago. His most recent contribution to Critical Inquiry is “Sex and the Emergence of Sexuality”. (shrink)

In real-time, Twitter strongly imprints world events, popular culture, and the day-to-day; Twitter records an ever growing compendium of language use and change; and Twitter has been shown to enable certain kinds of prediction. Vitally, and absent from many standard corpora such as books and news archives, Twitter also encodes popularity and spreading through retweets. Here, we describe Storywrangler, an ongoing, day-scale curation of over 100 billion tweets containing around 1 trillion 1-grams from 2008 to 2020. For each day, we (...) break tweets into 1-, 2-, and 3-grams across 150+ languages, record usage frequencies, and generate Zipf distributions. We make the data set available through an interactive time series viewer, and as downloadable time series and daily distributions. We showcase a few examples of the many possible avenues of study we aim to enable including how social amplification can be visualized through ‘contagiograms’. (shrink)